Anaplastic lymphoma kinase-positive large B-cell lymphoma: A potential diagnostic pitfall
نویسندگان
چکیده
منابع مشابه
Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma: An Underrecognized Aggressive Lymphoma
Anaplastic lymphoma kinase-(ALK-) positive large B-cell lymphoma (ALK+ LBCL) is a rare, aggressive tumor characterized by an immunoblastic or plasmablastic morphologic appearance, expression of ALK, CD138, CD45, EMA, and often IgA by immunohistochemistry, and characteristic chromosomal translocations or rearrangements involving the ALK locus. The morphologic and immunophenotypic overlap of this...
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Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK(+) LBCL) represents a distinct subtype of mature B-cell neoplasms in the most recent WHO classification of hematolymphoid neoplasms. It has a characteristic immunoblastic/plasmablastic morphology, a distinct immunophenotypic profile and recurrent cytogenetic/molecular genetic abnormalities, and has been reported in both the adult an...
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Cytokeratin (pan) and epithelial membrane antigen (EMA) were considered as commonly useful epithelial markers to distinguish cancer from lymphoma, but the expression of cytokeratin (pan) and EMA had also been seen in some lymphomas. Here, we presented an unusual case of anaplastic large cell lymphoma (ALCL) absence of some lymphoid markers (Including CD3, CD20, Pax-5, CD45Ro) and positive for c...
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INTRODUCTION Most primary stomach lymphomas are now recognized to originate from B-cell. Primary gastric anaplastic lymphoma kinase (ALK)-negative anaplastic large-cell lymphoma (ALCL) as shown in this case is very rare. CASE REPORT A 59-year-old man presented with a 1-month history of epigastric pain. Computed tomography showed a tumor in the stomach with perigastric lymphadenopathy. Biopsy ...
متن کاملBlood cytokine concentrations in pediatric patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the strength of the patients' anti-lymphoma immunity. We systematically correlated pre...
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ژورنال
عنوان ژورنال: Indian Journal of Pathology and Microbiology
سال: 2015
ISSN: 0377-4929
DOI: 10.4103/0377-4929.155332